Respiratory Network Mice Alters the Anoxic Response of the Isolated Long-Term Deprivation of Substance P in PPT-A Mutant
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Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network.
The aim of this study was to elucidate the role of the neuromodulator substance P and its related tachykinin neurokinin A (NKA) in the homeostasis of respiratory activity. Respiratory activities, in form of fictive eupneic and sigh activities, were recorded extracellularly from the preBötzinger complex (PBC) in normoxic and anoxic conditions using medullary slice preparations. The effect of a b...
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Low threshold Ca2+ currents mediated by T-type channels underlie burst spike activities of relay neurons in the thalamus. We have previously reported that knock-out mice for T-type channels show an enhanced nociceptive response to visceral pain, accompanied by an increase in tonic spikes in the absence of burst spikes in thalamic relay neurons. These results raised a possibility that T-type cha...
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تاریخ انتشار 2002